LAB PUBLICATIONS

click on a bullet to see the abstract (usually from PubMed)

Kleene, S.J. and Kleene, N.K. (2021) Inward calcium current through the polycystin-2-dependent channels of renal primary cilia. Am. J. Physiol. Renal Physiol. 320, F1165-F1173.
Kleene, S.J., Siroky, B.J., Landero-Figueroa, J.A., Dixon, B.P., Pachciarz, N.W., Lu, L., and Kleene, N.K. (2019) The TRPP2-dependent channel of renal primary cilia also requires TRPM3. PLoS ONE. 18, e0214053.
Siroky, B.J., Kleene, N.K., Kleene, S.J., Varnell, C.D., Comer, R.G., Liu, J., Lu, L., Pachciarz, N.W., Bissler, J.J., and Dixon, B.P. (2017) Primary cilia regulate the osmotic stress response of renal epithelial cells through TRPM3. Am. J. Physiol. Renal Physiol. 312, F791-F805.
Kleene, S.J. and Kleene, N.L. (2017) The native TRPP2-dependent channel of murine renal primary cilia. Am. J. Physiol. Renal Physiol. 312, F96-F108.
Nauli, S.M., Pala, R., and Kleene, S.J. (2016) Calcium channels in primary cilia. Curr. Opin. Nephrol. Hypertens. 25, 452-458.
Flannery, R.J., Kleene, N.K., and Kleene, S.J. (2015) A TRPM4-dependent current in murine renal primary cilia, Am. J. Physiol. Renal Physiol. 309, F697-F707; see also the journal's Editorial Focus on this article.
Kleene, S.J. and Van Houten, J.L. (2014) Electrical signaling in motile and primary cilia. BioScience 64, 1092-1102.
Kleene, N.K. and Kleene, S.J. (2012) A method for measuring electrical signals in a primary cilium. Cilia 1, 17.
Griff, E.R., Kleene, N.K., and Kleene, S.J. (2012) A selective PMCA inhibitor does not prolong the electroolfactogram in mouse. PLoS ONE 7, e37148.
French, D.A., Badamdorj, D., and Kleene, S.J. (2010) Spatial distribution of calcium-gated chloride channels in olfactory cilia. PLoS ONE 5, e15676.
Kleene, S.J. (2009) Identifying olfaction's 'other channels'. J. Physiol. 587, 4135-4136.
Kleene, S.J. (2009) Limits of calcium clearance by plasma membrane calcium ATPase in olfactory cilia. PLoS ONE 4, e5266.
Kleene, S.J. (2008) The electrochemical basis of odor transduction in vertebrate olfactory cilia. Chem. Senses 33, 839-859.
Badamdorj, D., French, D.A., Edwards, D., and Kleene, S.J. (2008) Identification of Cl(Ca) channel distributions in olfactory cilia. Math. Method. Appl. Sci. 31, 1860-1873.
Smith, D.W., Thach, S.S., Marshall, E.L., Mendoza, M.-G., and Kleene, S.J. (2008) Mice lacking NKCC1 have normal olfactory sensitivity. Physiol. Behav. 93, 44-49.
Nickell, W.T., Kleene, N.K., and Kleene, S.J. (2007) Mechanisms of neuronal chloride accumulation in intact mouse olfactory epithelium. J. Physiol. 583, 1005-1020.
Flannery, R.J., French, D.A., and Kleene, S.J. (2006) Clustering of cyclic-nucleotide-gated channels in olfactory cilia. Biophys. J. 91, 179-188.
French, D.A., Flannery, R.J., Groetsch, C.W., Krantz, W.B., and Kleene, S.J. (2006) Numerical approximation of solutions of a nonlinear inverse problem arising in olfaction experimentation. Math. Comput. Model. 43, 945-956.
Nickell, W.T., Kleene, N.K., Gesteland, R.C., and Kleene, S.J. (2006) Neuronal chloride accumulation in olfactory epithelium of mice lacking NKCC1. J. Neurophysiol. 95, 2003-2006.
Pun, R.Y.K. and Kleene, S.J. (2004) An estimate of the resting membrane resistance of frog olfactory receptor neurones. J. Physiol. 559, 533-540.
Pun, R.Y.K. and Kleene, S.J. (2003) Contribution of cyclic-nucleotide-gated channels to the resting conductance of olfactory receptor neurons. Biophys. J. 84, 3425-3435.
Kleene, S.J. (2002) The calcium-activated chloride conductance in olfactory receptor neurons. Curr. Topics Membr. 53, 119-134.
Pun, R.Y.K. and Kleene, S.J. (2002) Outward currents in olfactory receptor neurons activated by odorants and by elevation of cyclic AMP. Cell Biochem. Biophys. 37, 15-26.
Nickell, W.T., Pun, R.Y.K., Bargmann, C.I., and Kleene, S.J. (2002) Single ionic channels of two Caenorhabditis elegans chemosensory neurons in native membrane. J. Membr. Biol. 189, 55-66.
Kleene, S.J. (2000) Spontaneous gating of olfactory cyclic-nucleotide-gated channels. J. Membr. Biol. 178, 49-54.
Frings, S., Reuter, D., and Kleene, S.J. (2000) Neuronal Ca2+-activated Cl¯ channels - homing in on an elusive channel species. Prog. Neurobiol. 60, 247-289.
Kleene, S.J. (1999) Both external and internal calcium reduce the sensitivity of the olfactory cyclic nucleotide-gated channel to cAMP. J. Neurophysiol. 81, 2675-2682.
Kleene, S.J. (1997) High-gain, low-noise amplification in olfactory transduction in the frog. Biophys. J. 73, 1110-1117.
Larsson, H.P., Kleene, S.J., and Lecar, H. (1997) Noise analysis of ion channels in non-space-clamped cables: estimates of channel parameters in isolated olfactory cilia. Biophys. J. 72, 1193-1203.
Kleene, S.J. and Pun, R.Y.K. (1996) Persistence of the olfactory receptor current in a wide variety of extracellular environments. J. Neurophysiol. 75, 1386-1391.
Kleene, S.J. (1995) Patch-clamping of whole olfactory cilia. In: Experimental Cell Biology of Taste and Olfaction / Current Techniques and Protocols (A.I. Spielman and J.G. Brand, eds.). Boca Raton, FL: CRC Press, pp. 347-352.
Kleene, S.J. (1995) Block by external calcium and magnesium of the cyclic-nucleotide-activated current in olfactory cilia. Neuroscience 66, 1001-1008.
Kleene, S.J. and Cejtin, H.C. (1994) Solving buffering problems with Mathematica software. Anal. Biochem. 222, 310-314.
Kleene, S.J., Gesteland, R.C., and Bryant, S.H. (1994) An electrophysiological survey of frog olfactory cilia. J. Exp. Biol. 195, 307-328.
Pun, R.Y.K., Kleene, S.J., and Gesteland, R.C. (1994) Guanine nucleotides modulate steady-state inactivation of voltage-gated sodium channels in frog olfactory receptor neurons. J. Membr. Biol. 142, 103-111.
Kleene, S.J. (1994) Inhibition of olfactory cyclic nucleotide-activated current by calmodulin antagonists. Br. J. Pharmacol. 111, 469-472.
Kleene, S.J. (1993) Origin of the chloride current in olfactory transduction. Neuron 11, 123-132.
Kleene, S.J. (1993) The cyclic nucleotide-activated conductance in olfactory cilia: effects of cytoplasmic Mg2+ and Ca2+. J. Membr. Biol. 131, 237-243.
Kleene, S.J. (1993) A simple intrapipette salt bridge. J. Neurosci. Methods 46, 11-16.
Kleene, S.J. (1992) Basal conductance of frog olfactory cilia. Pflügers Arch. 421, 374-380.
Kleene, S.J. and Gesteland, R.C. (1991) Calcium-activated chloride conductance in frog olfactory cilia. J. Neurosci. 11, 3624-3629.
Pun, R.Y.K. and Gesteland, R.C. (1991) Somatic sodium channels of frog olfactory receptor neurones are inactivated at rest. Pflügers Arch. 418, 504-511.
Kleene, S.J. and Gesteland, R.C. (1991) Transmembrane currents in frog olfactory cilia. J. Membr. Biol. 120, 75-81.
Daston, M.M., Adamek, G.D., and Gesteland, R.C. (1990) Ultrastructural organization of receptor cell axons in frog olfactory nerve. Brain Res. 537, 69-75.
Duncan, H.J., Nickell, W.T., Shipley, M.T., and R. C. Gesteland (1990) Organization of projections from olfactory epithelium to olfactory bulb in the frog, Rana pipiens. J. Comp. Neurol. 299, 299-311.
Pixley, S.K. and Pun, R.Y.K. (1990) Cultured rat olfactory neurons are excitable and respond to odors. Brain Res. Dev. Brain Res. 53, 125-130.
Lidow, M.S., Gesteland, R.C., Shipley, M.T., and Kleene, S.J. (1987) Comparative study of immature and mature olfactory receptor cells in adult frogs. Dev. Brain Res. 31, 243-258.
Lidow, M.S., Kleene, S.J., and Gesteland, R.C. (1986) Suppression of mitotic activity and synchronization of cell development in olfactory epithelium. Dev. Brain Res. 28, 145-162.
Gesteland, R.C. (1986) Speculations on receptor cells as analyzers and filters. Experientia 42, 287-291.
Kleene, S.J. (1986) Bacterial chemotaxis and vertebrate olfaction. Experientia 42, 241-250.
Adamek, G.D., Gesteland, R.C., Mair, R.G., and Oakley, B. (1984) Transduction physiology of olfactory receptor cilia. Brain Res. 310, 87-97.
Kleene, S.J. and Gesteland, R.C. (1983) Dissociation of frog olfactory epithelium. J. Neurosci. Methods 9, 173-183.
Gesteland, R.C., Yancey, R.A., and Farbman, A.I. (1982) Development of olfactory receptor neuron selectivity in the rat fetus. Neuroscience 7, 3127-3136.
Mair, R.G. and Gesteland, R.C. (1982) Response properties of mitral cells in the olfactory bulb of the neonatal rat. Neuroscience 7, 3117-3125.
Mair, R.G., Gellman, R.L. and Gesteland, R.C. (1982) Postnatal proliferation and maturation of olfactory bulb neurons in the rat. Neuroscience 7, 3105-3116.
Mair, R.G., Gesteland, R.C., and Blank, D.L. (1982) Changes in morphology and physiology of olfactory receptor cilia during development. Neuroscience 7, 3091-3103.
Kleene, S.J. and Gesteland, R.C. (1981) Dissociation of frog olfactory epithelium with N-ethylmaleimide. Brain Research 229, 536-540.
Gesteland, R.C. and Sigwart, C.D. (1977) Olfactory receptor units--a mammalian preparation. Brain Res. 133, 144-149.
Farbman, A.I. and Gesteland, R.C. (1974) Fine structure of olfactory epithelium in the mud puppy, Necturus maculosus. Am. J. Anat. 139, 227-243.
Getchell, M.L. and Gesteland, R.C. (1972) The chemistry of olfactory reception: stimulus-specific protection from sulfhydryl reagent inhibition. Proc. Natl. Acad. Sci. USA 69, 1494-1498.
Gesteland, R.C., Lettvin, J.Y., and Pitts, W.H. (1965) Chemical transmission in the nose of the frog. J.Physiol. 181, 525-529.
Lettvin, J.Y. and Gesteland, R.C. (1965) Speculations on smell. Cold Spring Harb. Symp. Quant. Biol. 30, 217-225.


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